Why Miracle Mist Works and why it helps so many different ailments.
For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a hormone -- auxin -- interacts with its hormone receptor, called TIR1. Their report also may have important implications for the treatment of human disease, because TIR1 is similar to human enzymes that are known to be involved.
"Learning that auxin regulates TIR1 is a huge advance" said IU Bloomington biologist Mark Estelle. "It's a bonus for us that TIR1 is related to proteins in other organisms, including humans. Some of TIR1's human relatives play a role in different human concerns, and it is possible that our work will eventually lead to new drugs."
Until now it was believed enzymes like TIR1, called ubiquitin ligases, could only be controlled through protein-protein interactions. Ubiquitin ligases influence growth and light response in cells, poison mitigation in yeasts and also cancerous cell division in humans.
"Although ubiquitin ligases have long been recognized as potential drug targets for treating cancers and other human diseases, it's been a bumpy road for scientists to come up with a feasible approach," said University of Washington School of Medicine pharmacologist Ning Zheng, who led the research. "The mechanism by which auxin works points out a new direction for us to develop therapeutic compounds targeting ubiquitin ligases."
The scientists extracted and purified TIR1. By x-raying crystals of the protein, Zheng, Estelle and colleagues determined the enzyme's three-dimensional structure -- a first for hormone receptors. The scientists then soaked the crystal in a solution containing auxin and repeated the x-ray treatment to determine where the auxin had bound. Finally the scientists added a peptide that TIR1 is known to bind and modify. The scientists learned that auxin is a sort of "molecular glue" that improves the ability of TIR1 to bind its peptide target. In the absence of auxin, TIR1 does not bind its target as tightly. Because the architecture of TIR1 is highly conserved among other ubiquitin ligases, including those in human cells, the scientists expect other ubiquitin ligases may be affected by small molecules like auxin. Organic chemists could, hypothetically, synthesize such molecules as a new type of benifical drug.
"A number of human disorders including Parkinson's disease, and colon and breast cancers, are caused by defective interactions between ubiquitin ligases and their substrate polypeptides. What this hormone tells us is that it might be possible to rescue these interactions using small molecules," said Zheng.
Two teams of scientists reported in May 2005 (also in Nature) that TIR1 is, in fact, a receptor for auxin. Estelle led one of the two teams; Ottoline Leyser of the University of York led the other. The discovery put to end conjecture about how auxin initiates growth and light response, but it also caught the attention of those studying the molecular biology and biochemistry of human ubiquitin ligases.
Xu Tan and Changxue Zheng (University of Washington School of Medicine), Luz Irina Calderon-Villalobos (Indiana University Bloomington), and Michal Sharon and Carol Robinson (University of Cambridge) also contributed to the report.
Source: Indiana University.(Paraprased)
Kinetin is a type of compound known as a cytokinin. These compounds act as hormones where they're involved in the growth and differentiation of cells. In cells, they serve as growth regulators. At the same time, they protect the DNA and cell membranes of the cells against damage due to oxygen exposure by acting as antioxidants. Cytokinins like kinetin also seem to slow down the aging process in cells, keeping them healthy and vital longer.
Kinetin appears to have similar effects on human cells. In one study, kinetin was added to the culture medium of human fibroblasts. When this happened, the cells showed delayed signs of aging compared to cells that weren't exposed to it. When researchers removed kinetin from the cultures, the cells again showed typical signs of aging.
Another example that supports kinetin's anti-aging properties was a study carried out in fruit flies. Fruit flies have an average lifespan of about a month, but when researchers added kinetin to their diet, it more than doubled the lifespan of female fruit flies, although it reduced their ability to reproduce. A low dose was most effective in this study since high oral doses were toxic to fruit flies.
Does kinetin have skin anti-aging benefits? Like other cells, skin cells are vulnerable to oxidative damage as a result of exposure to sunlight and environmental pollutants. Oxidative damage plays a major role in skin aging by disrupting cells and activating enzymes that break down collagen and elastin, two essential proteins that give skin its support and youthful firmness. Because of these properties, a pharmaceutical company added kinetin to a skin care product called Kinerase in 1994.
Kinerase is marketed as a plant-based alternative to topical retinoids like Retin-A. Retinoids have significant skin anti-aging benefits but also frequently cause skin irritation, redness and peeling. For this reason, some people can't tolerate them. Products like kinerase that contain kinetin are marketed as a "gentler" alternative to retinoids, offering similar anti-aging benefits without the same degree of skin irritation.
Does it work? Small studies support the skin anti-aging benefits of kinetin. A split-face study published in Dermatology Times in 2002 revealed that the side of the face exposed to kinetin for three months showed a decrease in the appearance of fine wrinkles, better skin texture and clarity and lightening of pigmented areas when compared to the opposite half of the face. Other small studies have shown similar benefits. Whether or not it's as effective as retinoids for treating aging skin is still unclear, although it appears to cause fewer side effects and is better tolerated. Unlike prescription-strength retinoids, Kinerase and other products that contain kinetin are available without a prescription.
Is kinetin safe?
Kinetin has an excellent safety profile. The Environmental Working Group's Skin Deep Cosmetics Database classifies it as a low-hazard cosmetic ingredient. It's not uncommon for kinetin users to experience mild redness, irritation and burning when they first start using it. This usually resolves over time. Most people can tolerate kinetin, even if they experience problems with topical retinoids or have sensitive skin. It typically doesn't cause allergies or clog pores.
All in all, kinetin offers many of the benefits of topical retinoids without the same degree of redness and skin irritation. It appears to soften and reduce fine lines and wrinkles, improve skin texture and clarity and lighten mottled skin pigment. Plus, it's available without a prescription. It's a good choice for people with sensitive skin and those who have tried retinoids and haven't been able to tolerate them because of skin irritation, redness and peeling. Products that contain kinetin can cause some skin irritation initially, but it's usually less than what people experience with prescription-strength retinoids.
Humic Acid - Nature's Best Kept Secret!
Until recently, most of the world has been kept in the dark about a "miraculous" medical discovery that is so safe, powerful and effective that "doctors" spanning the globe have used it for thousands of years with amazing results. Called the "missing link" to optimum health and nutrition by leading scientists, medical studies have shown that this "secret extract" has the ability to change one's life for the better.
Scientists have discovered this "missing link" in our food chain, and can see that the rapidly increasing degenerative diseases worldwide may be directly related to the absence of this substance in the human diet. Now, experts know that more than vitamins and minerals are required for optimal health, and this third nutritional element may be equally important.
This breakthrough discovery is supported by little-known and even secret medical research coming from top institutions around the world... medical schools, hospitals, clinics, and pharmaceutical laboratories. Most of the world doesn't yet know about this amazing discovery and for some very good reasons: Scientists didn't know it existed, couldn't detect it, and when they finally did identify it, it was so complex that they couldn't understand it.
Some of the medical institutions doing the research are more interested in making enormous profits from developing synthetic patented drugs, which is why they prefer you not know about this natural alternative.
Pharmaceutical companies have been rushing to patent synthetic versions of this natural substance, and dozens of patents have been approved. Yet Mother Nature has them all beat because they'll never be able to duplicate her handiwork. This substance is far too complex!
An estimated 80% of pharmaceutical drugs are tiny, isolated synthetic fractions of this WHOLE AND COMPLETE "missing link" from nature.
So what, you may be asking yourself, is this "Miracle Substance?" The answer lies in the Earth's very own ancient and rich soil deposits more commonly known as Humus. Humus is that organic portion of soil that remains after millions of years of microbial decomposition of plants and vegetation. Further decomposition of these ancient remains form our oil and coal deposits. But geologists have found another most unusual strata that are called humic deposits. They are quite rare and can be found only in certain areas of the world. It is these deposits that are exceedingly rich in our miraculous, little known substance called Humic Acid. What Is Humic Acid?
Humic acid, by definition, is a fraction of humic substances composed of a long chain molecule, which is high in molecular weight, dark brown in color and soluble in an alkaline solution. Again, little is known about this amazing molecular complex but what is known is that Humic acid, depending on the need for balance in the whatever situation, can behave as both a donor or acceptor of electrons. What this means in laymen's terms is that it will bind to both positive and negatively charged ions making it the most powerful free-radical scavenger and natural anti-oxidant known. Which makes sense, since Humic Acid has long been used in various ancient cultures as folk remedies for a wide variety of illnesses?
The following are excerpts from Bard, R. Effects of Humic Acid on Animals and Humans, 2002, pages 3-7, a review of current research of the many traditional uses for Humic Acid:
"Humates boaster (sic) the immune system. Dr. Daryl See, M.D., Immunologist of UCLA Medical School suggests that the mechanism is related to the humates ability to complex sugars within the body. "The abundance of these complex sugars allows the body to manufacture glycoproteins that attach to the killer and T cell acting as a modulator or communication link between the cells. This regulates the immune system cells and prevents either T or Killer cells from becoming out of balance.
Types Of T Cells
T cells are a subset of lymphocytes that play a large role in the immune response. The abbreviation "T" stands for thymus, the organ in which their final stage of development occurs.
Cytotoxic "Killer" T cells (CD8+) destroy infected cells. These cells function as "killer" or cytotoxic cells because they are able to destroy target cells which express specific antigens that they recognize.
Helper T cells (CD4+) are "middlemen" in the immune response. When they get activated, they proliferate and secrete cytokines that regulate or "help" effector lymphocyte function. They are known as one of the targets of HIV infection, and the decrease of CD4+ T cells results in AIDS. Some helper T cells secrete cytokines that turn off the immune response once an antigen has been eliminated from the body.
Suppressor T cells (also known as regulatory T cells) suppress activation of the immune system and maintain immune system homeostasis. Failure of regulatory T cells to function properly may result in autoimmune diseases in which the immunocytes attack healthy cells in the body.
"Along this same line, burn victims and radiation sickness experience immune system responses that attack the body's dead cells creating unwanted infections.
"Humates cause the immune system to recognize its own dead cells thereby reducing infection. Baylor Medical School is currently researching humates both topically applied and internally dosed for burn victims to reduce infections.
"Russian scientists are using the same principle for the treatment of radiation sickness. Sodium humate has been found to increase the lifespan of mongrel rats exposed to lethal doses of cobalt radiation8."*
"Humates are effective media additives for the production of antibiotics in the soil.
Humic substances have long been known to exhibit anti-viral properties in particular rhinoviruses.
What Is A Rhinovirus?
A rhinovirus is a virus member of the family Picornaviridae. The rhinoviruses are single stranded positive sense RNA viruses.
They are the most common viral infective agents in humans. The most well known disease caused by rhinoviruses is the common cold. There are over 100 serologic virus types which cause cold symptoms and rhinoviruses are responsible for around 50% of all cases. The name comes from the Greek rhin, which means "nose".
Viral pathogens for which soil-extract materials have been shown to be effective include in particular Coxsackie virus A9 (34), herpes simplex virus type 1 and 2 10 11 21 29 36 37 human immunodeficiency virus (HIV) 22 30 31 38 39, influenza type A and B22 35 38 40, as well as other respiratory tract infections.33 34 35 37 41.
The mechanism whereby humic substances inhibit the cytopathicity (sic) of a number of viruses has been studied in some depth. It is thought that the materials prevent viral replicating by sorbing onto the viral envelope protein and thereby blocking the sorption of viral particles to cell surfaces31.
What Does "Sorbing" Mean?
Sorb: To take up and hold, as by absorption or adsorption. Humic acids have also been employed as veterinary medicine therapy successfully employing peat mull (extracted humic acid) to prevent the transmission of foot and mouth disease in pigs(33). Humate is a pharmacy that raises non-specific organism resistance. This fact was confirmed by using such models as atoxic anemia, toxic hepatitis, peptic ulcer and hypercholesterolimia15."*
"Fulvic acid, a component of humate, is a strong chelator. It is unique in its chelating ability. Life sustaining minerals, when chelated by fulvic, are placed in a chemical state (phyto-state) such that they are readily absorbed by the cell or organism. Toxic heavy metals are also chelated but placed in a chemical state that is difficult for cellular absorption.
What Does Chelate Mean?
To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate (A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions).
"Fulvic acid in the soil acts as a filter for toxic metals. It will grab a toxic metal and immobilize it which prevents it from migrating or chemically reacting.
"When crops are grown on soils deficient in fulvic acid, toxic metals can be absorbed by the plant and passed into the food chain. Many of our foods present today are grown under conditions of "worn out" soil. As a result, more toxic metals are being ingested. Fulvic acid has the capability of removing these toxic metals from the body." *
* These statements have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.
Copper peptides are naturally occurring complexes that have been used for a variety of purposes in skin and hair care products since the 1990s. The complexes are a combination of the element copper and three amino acids. In the human body, copper peptides are found in trace amounts in blood plasma, saliva and urine. When used in skin care products, copper peptides can be made in a laboratory setting by combining a solution that contains copper with a substance that is similar to a protein powder.
Investigations into the benefits of copper peptides began in 1973 when biochemist Loren Pickart isolated the complexes from plasma samples. Pickart began searching for copper peptides when he discovered that liver cells obtained from people over the age of 60 could be revitalized by placing them in blood samples sourced from younger people. His goal was to determine precisely what was in the blood that caused this incredible rejuvenation of the cells, and when he identified that substance, copper peptides had been officially discovered.
The research begun by Pickart continued for decades and the results of his work have been reviewed, duplicated and confirmed by numerous independent scientists and physicians. In 1997, the first skin care products that contain copper peptides were released for sale and now, numerous brands offer formulas that are enriched with the complexes.
Copper peptides have been clinically shown to offer a wide variety of benefits for the skin and hair. Often, the complexes are used in skin care lotions, creams and serums designed to reduce the appearance of fine lines and wrinkles. Just as copper peptides had the ability to regenerate liver cells in Pickart's study, the ingredient can also rejuvenate skin cells in aging tissue, boosting the production of collagen and elastin. Levels of these structural proteins naturally decrease with age, and by increasing the amount available in the tissue, the skin can regain elasticity and strength. This makes many signs of aging less noticeable and slows down the aging process.
The anti-aging benefits of copper peptides are also due to their ability to promote the production of glycosaminoglycans like hyaluronic acid. These substances are found in the connective tissue and fluids in the human body and become depleted with age. The glycosaminoglycans are vital for helping the skin tissue remain plump and supple, and by supplementing their levels, the tissue can fill out and fine lines and wrinkles become less noticeable. Hyaluronic acid also helps the skin retain moisture, making copper peptides beneficial ingredients for products intended to treat dry skin.
Clinical research has established that copper peptides are antioxidants, nutrients that counteract the oxidizing effects of environmental particles called free radicals. Your skin is exposed to free radicals on a daily basis, and over time, the oxidation that they cause can result in cellular damage, which leads to the development of signs of aging. Because copper peptides neutralize free radicals, they can help prevent expression lines and wrinkles from developing prematurely.
In addition to their use in anti-aging skin care products, copper peptides are often found in shampoos and treatments designed to combat hair loss. Studies show that copper peptides have a positive effect on the hair follicles and can stimulate regrowth in areas of thinning and baldness. Its effects are similar to that of the medication minoxidil, which has been used for hair loss treatment for decades. Copper peptides are also capable of reducing the amount of hair loss that occurs due to chemotherapy treatments for cancer for some people.
Due to their natural presence in the human body, copper peptides are not known to cause side effects;however, some products that contain copper peptides could cause irritation and redness in people with sensitive skin due to other ingredients in their formulas.
Research into the benefits of copper peptides continues to this day. The ingredient has been shown in some studies to have the potential to absorb ultraviolet rays from the sun, to stimulate fingernail growth and to provide other benefits to the skin, hair and nails. The potential for the inclusion of copper peptides in new types of skin care products is impressive, and more and more top skin care brands are finding ways to incorporate these powerful natural complexes in their formulas each year
Thanks for introducing me to Miracle Mist. It worked great on the crows feet by my eyes. As you know I had surgery on my back to remove a tumor from my spine. After my surgery I used Miracle Mist twice a day on the scare and it looks great. You can hardly tell in the tattooed area that I had surgery. I also used it on the radiation burns after my treatments and the lesions from my bone cancer. It would sooth the pain and restore my skin over night. My doctors were amazed how well it healed and all I used was the Miracle Mist. I can't believe how well it worked all over my body. I would recommend Miracle Mist to anyone having radiation treatments.
Thank you for the Miracle Mist. It has made the biggest difference in the wrinkles on my for head. I use the spray twice a day and the wrinkles are gone. I still can see them but barely. I don't feel them like I did before when I touch my forehead. My boy friend has even noticed the difference. I asked my 13 year old daughter to use it on her acne. It took away the redness right away and made the biggest difference in the duration of it. Its just the best stuff ever.
Every body should use this. thanks again
To Whom It May Concern:
Ed Burns, a vendor at the Bloomington Community Farmers Market, inquired about selling a spray made from worm castings that he said was beneficial for a wide range of skin conditions. While I was skeptical of the claims, it fit within the established rules of the Market, so I let him know he was welcome to sell it.Being a curious person and someone whose skin has taken a beating from working outside most of my life, I decided to give Miracle Mist a try. I've been using it for five months now and am pleased with the results. I still have wrinkles, but fewer of them and they quote are softer. I have also noticed my age spots have faded and some have disappeared altogether.
I'm happy to say, I'm a big fan of Miracle Mist.
6181 East Kent Rd.
Bloomington, IN 47401